Mitochondrial Actions for Fat Browning and Energy Expenditure in White Adipose Tissue
نویسندگان
چکیده
1Interdisciplinary Program in Health Sciences, Institute of Physical Activity Sciences and Sport, Cruzeiro do Sul University, Sao Paulo, Brazil 2Department of Biological Sciences, Institute of Environmental Sciences, Chemical and Pharmaceutical, Federal University of São Paulo, Diadema, Brazil 3Department of Physiology and Biophysics, Institute of Biomedical Sciences 1, University of Sao Paulo, Sao Paulo, Brazil
منابع مشابه
AHNAK deficiency promotes browning and lipolysis in mice via increased responsiveness to β-adrenergic signalling
In adipose tissue, agonists of the β3-adrenergic receptor (ADRB3) regulate lipolysis, lipid oxidation, and thermogenesis. The deficiency in the thermogenesis induced by neuroblast differentiation-associated protein AHNAK in white adipose tissue (WAT) of mice fed a high-fat diet suggests that AHNAK may stimulate energy expenditure via development of beige fat. Here, we report that AHNAK deficien...
متن کاملβ-Lapachone Prevents Diet-Induced Obesity by Increasing Energy Expenditure and Stimulating the Browning of White Adipose Tissue via Downregulation of miR-382 Expression.
There has been great interest in the browning of fat for the treatment of obesity. Although β-lapachone (BLC) has potential therapeutic effects on obesity, the fat-browning effect and thermogenic capacity of BLC on obesity have never been demonstrated. Here, we showed that BLC stimulated the browning of white adipose tissue (WAT), increased the expression of brown adipocyte-specific genes (e.g....
متن کاملCardiac natriuretic peptides promote adipose ‘browning’ through mTOR complex-1
OBJECTIVE Activation of thermogenesis in brown adipose tissue (BAT) and the ability to increase uncoupling protein 1 (UCP1) levels and mitochondrial biogenesis in white fat (termed 'browning'), has great therapeutic potential to treat obesity and its comorbidities because of the net increase in energy expenditure. β-adrenergic-cAMP-PKA signaling has long been known to regulate these processes. ...
متن کاملWhite adipose tissue browning and obesity
Obesity and metabolic disorders are major health concerns worldwide. Although a range of therapies have been developed, these pharmaceutical treatments often have adverse side effects or limited efficacy. Therefore, there is a growing need of novel therapeutics to prevent or treat obesity. Obesity is thought to be caused by an imbalance between energy intake and energy consumption. Increasing e...
متن کاملBurn Induces Browning of the Subcutaneous White Adipose Tissue in Mice and Humans
Burn is accompanied by long-lasting immuno-metabolic alterations referred to as hypermetabolism that are characterized by a considerable increase in resting energy expenditure and substantial whole-body catabolism. In burned patients, the length and magnitude of the hypermetabolic state is the highest of all patients and associated with profoundly increased morbidity and mortality. Unfortunatel...
متن کامل